Author(s):
Sampoornam. W, Sona Shaji, B. Manisha
Email(s):
drsampoornamwebster@gmail.com , sampoornamwebster@yahoo.co.in
DOI:
10.52711/ijnmr.2026.17 
Address:
Sampoornam. W1, Sona Shaji, B. Manisha2
1Principal, Bhavani College of Nursing, Erode, Tamil Nadu, India.
2BSc Nursing Students, Bhavani College of Nursing, Erode, Tamil Nadu, India.
*Corresponding Author
Published In:
Volume - 5,
Issue - 2,
Year - 2026
ABSTRACT:
Antipsychotic medications form the cornerstone of schizophrenia management, yet temporary discontinuation known as drug holiday is sometimes considered to reduce side effects or assess relapse risk. This critical literature review evaluates the efficacy, risks, and nursing implications of drug holiday in schizophrenia patients. Databases including PubMed, PsycINFO, CINAHL and Google Scholar were searched (2015-2025) yielding 14 studies. Findings reveal high relapse rates (40-80% within 3-6 months), increased hospitalization and symptom exacerbation outweighing benefits like side effect relief. Evidence strongly advises against routine drug holiday, favouring gradual tapering under supervision. Psychiatric nurses play a key role in monitoring adherence and relapse prevention. Recommendations emphasize patient education and shared decision-making.
Cite this article:
Sampoornam. W, Sona Shaji, B. Manisha. A Critical Review of Temporary Antipsychotic Discontinuation (Drug Holiday) in Schizophrenia. A and V Pub International Journal of Nursing and Medical Research. 2026; 5(2):75-7. doi: 10.52711/ijnmr.2026.17
Cite(Electronic):
Sampoornam. W, Sona Shaji, B. Manisha. A Critical Review of Temporary Antipsychotic Discontinuation (Drug Holiday) in Schizophrenia. A and V Pub International Journal of Nursing and Medical Research. 2026; 5(2):75-7. doi: 10.52711/ijnmr.2026.17 Available on: https://www.ijnmronline.com/AbstractView.aspx?PID=2026-5-2-5
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